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研究成果

Acrosome-reacted mouse spermatozoa recovered from the perivitelline space can fertilize other eggs.
Inoue N., Satouh Y., Ikawa M., Okabe M., Yanagimachi R.
Proceedings of the National Academy of Sciences of the United States of America, 108(50):20008-11.

Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras.
Isotani A., Hatayama H., Kaseda K., Ikawa M., Okabe M.
Genes to Cells, 16(4):397-405.

EphrinA/EphA signal facilitates insulin-like growth factor-I-induced myogenic differentiation through suppression of the Ras/extracellular signal-regulated kinase 1/2 cascade in myoblast cell lines.
Minami M., Koyama T., Wakayama Y., *Fukuhara S. and Mochizuki N. (* Corresponding author)
Molecular Biology of the Cell, 22(18), 3508-3519.

Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of β-catenin.
Zhang J., **Fukuhara S., Sako K., Takenouchi T., Kitani H., Kume T., Koh G.Y. and **Mochizuki N. (**Co-corresponding authors)
The Journal of Biological Chemistry, 286, 8055-8066.

Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and ca2+/calmodulin-dependent protein kinases.
Nakamuta S., Funahashi Y., Namba T., Arimura N., Picciotto M. R., Tokumitsu H., Soderling T. R., Sakakibara A., MiyataT., Kamiguchi H., Kaibuchi K.
Science Signaling, 4(199): ra76.

Conjugation of both on-axis and off-axis light in Nipkow disk confocal microscope to increase availability of incoherent light source.
Saito K., Arai Y., Zhang J., Kobayashi K., Tani Y., and Nagai T.
Cell Structure and Function, in press.

Role of the KcsA Channel Cytoplasmic Domain in pH-Dependent Gating.
Hirano M., Onishi Y., Yanagida T., and Ide T.
Biophysical Journal, 101(9), 2157-2162.

A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28.
Kong, K.F., Yokosuka, T., Canonigo-Balancio, A.J., Isakov, N., Saito, T., and Altman, A.
Nature Immunology, 12(11), 1105-1112.

A fluorescence spotlight on the clockwork development and metabolism of bone.
Iimura, T., Nakane, A., Sugiyama, M., Sato, H., Makino, Y., Watanabe, T., Takagi, Y., Numano, R., Yamaguchi, A.
Journal of Bone and Mineral Metabolism, Jul 16, [Epub ahead of print].

Cooperation of p40phox with p47phox for Nox2 activation during FcγR-mediated phagocytosis--- Mechanism for acquisition of p40phox PI(3)P binding---
Ueyama, T., Nakakita, N., Nakamura, T., Kobayashi, T., Kobayashi, T., Son, J., Sakuma, M., Sakaguchi, H., Leto, T.L., Saito, N.
The Journal of Biological Chemistry, M111, 237289.

Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation.
Hashimoto-Tane, A., Yokosuka, T., Sakata-Sogawa, K., Sakuma, M., Ishihara, C., Tokunaga, M., Saito, T.
Immunity, 34, 919-31.

CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway.
Kometani, K., Yamada, T., Sasaki, Y., Yokosuka, T., Saito, T., Rajewsky, K., Ishiai, M., Hikida, M., Kurosaki, T.
The Journal of Experimental Medicine, 208, 1447-57.

β-Galactosidase Fluorescence Probe with Improved Cellular Accumulation Based on Spirocyclized Rhodol Scaffold. br /> Kamiya. M,, Asanuma. D,, Kuranaga. E,, Takeishi, A., Sakabe, M., Miura, M., Nagano, T., Urano, Y.
Journal of the American Chemical Society, 133(33), 12960-12963.

Lateral resolution enhancement of laser scanning microscopy by higher-order radially polarized mode beam.
Kozawa,Y.†, Hibi, T.†, Sato, A,, Horanai, H., Kurihara, M., Hashimoto, N., Yokoyama, H., Nemoto, T. and Sato, S. (†: equally contributed)
Optics Express, 19(17), 15947-15954.

Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb.
Sawada, M., Kaneko, N., Inada, H., Wake, H., Kato,, Y., Yanagawa, Y., Kobayashi, K., Nemoto, T., Nabekura, J. and Sawamoto, K.
The Journal of Neuroscience, 31, 11587-11596.

BCL6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity.
Kitano, M., Moriyama, S., Ando, Y., Hikida, M., Mori, Y., Kurosaki, T. and Okada, T.
Immunity, 34. 961-972.

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