Chimaerin suppresses Rac1 activation at the apical membrane to maintain the cyst structure.
Yagi S., Matsuda M. and Kiyokawa E.
PLoS ONE, 7(12): p. e52258.

Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis.
Sakurai A., Matsuda M. and Kiyokawa E.
The Journal of Biological Chemistry, 287(38): p. 31703-11.

Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors.
Kamioka Y., Sumiyama K., Mizuno R., Sakai Y., Hirata E., Kiyokawa E. and Matsuda M.
Cell Structure and Function, 37(1): p. 65-73.

Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance.
Yagi S., Matsuda M. and Kiyokawa E.
EMBO report, 13(3): p. 237-43.

FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells.
Kunida K., Matsuda M. and Aoki K.
Journal of Cell Science, 125(Pt 10): p. 2381-92.

A Novel Function of Noc2 in Agonist-Induced Intracellular Ca2+ Increase during Zymogen-Granule Exocytosis in Pancreatic Acinar Cells.
Ogata S., Miki T., Seino S., Tamai S., Kasai H., Nemoto T.
PLoS ONE, 7(5):e37048.

Observation of PDLCs by SHG laser scanning microscopy using a liquid crystal vector beam generator.
Tanabe A., Saito Y., Kurihara M., Hashimoto N.,Kozawa Y., Sato S., Hibi T., Nemoto T.
Proceedings of SPIE, 8279-2.

GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice.
Inada H., Watanabe M., Uchida T., Ishibashi H., Wake H.,Nemoto T., Yanagawa Y., Fukuda A., Nabekura J.
PLoS ONE, 6(12):e27048.

Luminescent proteins for high-speed single-cell and whole-body imaging.
Saito K., Chang Y. F., Horikawa K., Hatsugai N., Higuchi Y., Hashida M., Yoshida Y., Matsuda T., Arai Y. and Nagai T.
Nature Communications, 3:1262.

SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia.
Fujihara Y., Satouh Y., Inoue N., Isotani A., Ikawa M., Okabe M.
Development, 139(19):3583-9.

Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa.
Yamaguchi R., Fujihara Y., Ikawa M., Okabe M.
Molecular biology of the cell, 23(14):2671-9.

Tetraspanin-interacting protein IGSF8 is dispensable for mouse fertility.
Inoue N., Nishikawa T., Ikawa M., Okabe M.
Fertility and sterility, 98(2):465-70.

Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male infertility.
Tokuhiro K., Ikawa M., Benham A. M., Okabe M.
Proceedings of the National Academy of Sciences of the United States of America, 109(10):3850-5.

Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1.
Satouh Y., Inoue N., Ikawa M., Okabe M.
Journal of Cell Science, 125(Pt 21), 4985-90.

Rational Design of Highly Sensitive Fluorescence Probes For Protease and Glycosidase Based on Precisely Controlled Spirocyclization.
Sakabe M., Asanuma D., Kamiya M., Iwatate R., Hanaoka K., Terai T., Nagano T., Urano Y.
Journal of the American Chemical Society, in press.

Reelin-dependent ApoER2 downregulation uncouples newborn neurons from progenitor cells.
Pérez-Martínez F.J., Luque-Río Á., Sakakibara A., Hattori M., Miyata T., Luque J.M.
Biology Open, in press.

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus.
Ueda Y., Katagiri K., Tomiyama T., Yasuda K., Habiro K., Katakai T., Ikehara S., Matsumoto M., and Kinashi T.
Nature Communications, 3: 1098.

Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer.
Katakai T.
Frontiers in Immunology, 3: Article 200.

WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration.
Xie M.-J., Yagi H., Kuroda K., Wang C.-C., Komada M., Zhao H., Sakakibara A., Miyata T. Nagata K., Iguchi T., Sato M.
Cerebral Cortex, in press.

Highly Activatable and Environment-insensitive Optical Highlighters for Selective Spatiotemporal Imaging of Target Proteins.
Kobayashi T., Komatsu T., Kamiya M., Campos C., González-Gaitán M., Terai T., Hanaoka K., Nagano T., Urano Y.
Journal of the American Chemical Society, in press.

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
Yokosuka T., Takamatsu M., Kobayashi-Imanishi W., Hashimoto-Tane A., Azuma M., Saito T.
The Journal of Experimental Medicine, 209(6), 1201-1217.

Structural basis for mutual reliefof the Rac guanine nucleotide exchange factor DOCK2 andf its partner ELMO1 fromtheir autoinhibited forms.
Hanawa-Suetsugu K., Kukimoto-Niino M., Mishima-Tsumagari C., Akasaka R., Ohsawa N., Sekine S.,Ito T., Tochio N., Koshiba S., Kigawa T., Terada T., Shirouzu M., Nishikimi A., Uruno T., Katakai T., Kinashi T., Kohda D., Fukui Y., Yokoyama S.
Proceedings of the National Academy of Sciences of the United States of America, 109(9), 3305-3310.

DOCK8 is a Cdc42activator critical for interstitial dendritic cell migration during immuneresponses.
Harada Y., Tanaka Y., Terasawa M., PieczykM., Habiro K., Katakai T., Hanawa-Suetsugu K., Kukimoto-Niino M., Nishizaki T., Shirouzu M., Duan X., Uruno T., Nishikimi A., Sanematsu F., Yokoyama S., Stein j. V., Kinashi T., and Fukui Y.
Blood, 119(19), 4451-4461.

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.
Fukuhara S., Simmons S., Kawamura S., Inoue A., Orba Y., Tokudome T., Sunden Y., Ara Y., Moriwaki K., Ishida J., Uemura A., Kiyonari H., Abe T., Fukamizu A., Hirashima M., Sawa H., Aoki J., Ishii M., and Mochizuki N.
The Journal of Clinical Investigation, 122(4), 1416-1426.

Structural differences in the osteocyte network between the calvaria and long bone revealed by three-dimensional fluorescence morphometry, possibly reflecting distinct mechano-adaptations and sensitivities.
Himeno-Ando A., Izumi Y., Yamaguchi A., Iimura T.
Biochemical and Biophysical Research Communications, 414(2), 765-770.

蛍光タンパク質等のhumanized cDNAを配布しています。


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